Tumours reprogram their metabolism to maximize macromolecule biosynthesis for growth. However, which of the common tumour-associated metabolic activities are critical for proliferation remains unclear. Glutamate-derived glutamine is now shown to satisfy the glutamine needs of glioblastoma, indicating that glutamine anaplerosis is dispensable for growth.
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Krall, A., Christofk, H. Rethinking glutamine addiction. Nat Cell Biol 17, 1515–1517 (2015). https://doi.org/10.1038/ncb3278
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DOI: https://doi.org/10.1038/ncb3278
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